Science News
Discover the news and inspiring materials from the world of biotechnology.
How long might CAR-T cell therapy work?
In a remarkable medical milestone, a woman has remained cancer-free for an unprecedented 19 years following a pioneering CAR-T cell therapy administered during her childhood. This groundbreaking case offers renewed hope for the long-term efficacy of CAR-T cell treatments in combating rare pediatric cancers.
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Mabion Wins Best of Industry Insights Award for Biologics Outsourcing Article in Outsourced Pharma Best Of 2024
Mabion SMEs’s article has been awarded Best of Industry Insights in the Biologics Outsourcing category of the Outsourced Pharma Best Of 2024 awards.
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FDA approves first medication for obstructive sleep apnea: Eli Lilly’s Zepbound GLP-1 agonist
The FDA has approved Eli Lilly’s Zepbound (tirzepatide) as the first-ever medication for treating moderate to severe obstructive sleep apnea (OSA) in adults with obesity, providing a pharmacological alternative to CPAP machines and surgery.
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Biocon’s Yesintek receives EMA and FDA approval as the next ustekinumab biosimilar
Yesintek, a biosimilar to ustekinumab developed by Biocon, has received approval from both the EMA and FDA, joining other ustekinumab biosimilars like Amgen’s Wezlana and Alvotech’s Selarsdi.
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Lecanemab approved by EMA in early Alzheimer’s after re-evaluation
The European Medicines Agency (EMA) reversed its initial rejection and approved lecanemab (Leqembi) for early-stage Alzheimer’s, limiting its use to patients with one or no copies of the ApoE4 gene. The restriction of indication is intended to maximize the benefit-risk ratio of the new drug.
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Transplantation of stem cells islets cures patient from type 1 diabetes
Chinese scientists have reversed Type 1 diabetes in a patient by transplanting chemically-induced pluripotent stem-cell-derived islets (CiPSC islets), marking a significant medical breakthrough. The procedure reprogrammed the patient’s own fat cells into insulin-producing islets, eliminating the need for insulin therapy and reducing the risk of immune rejection frequently seen with donor-based transplants. Stable glycemic control was maintained at least for one year, with no registered complications.
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Nobel prize in medicine awarded to microRNA discoverers
This year’s Nobel prize in physiology or medicine has been awarded to Victor Ambros and Gary Ruvkun who discovered microRNAs (miRNAs) and elucidated their role in regulating gene expression. MicroRNAs are a class of small RNA molecules that reduce the expression of specific genes by binding to and disrupting their corresponding mRNAs. This regulation of gene expression pattern by miRNAs plays a key role in driving cell differentiation and determining cell fate. The discoveries of this year’s Nobel laureates are likely to pave the way for novel cancer therapies.
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Zolbetuximab demonstrates significant benefit in gastric cancer and receives approval in the EU
Zolbetuximab, a monoclonal antibody targeting CLDN18.2, demonstrated significant benefits in advanced gastric and gastroesophageal junction cancer. The trials reported improvement both in progression-free and overall survival, over chemotherapy alone, leading to the recent approval by EMA.
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